Editing of an Immunodominant Epitope of Glutamate Decarboxylase by HLA-DM
نویسندگان
چکیده
منابع مشابه
Editing of an immunodominant epitope of glutamate decarboxylase by HLA-DM.
HLA-DM stabilizes peptide-receptive class II alphabeta dimers and facilitates the capture of high affinity peptides, thus influencing the peptide repertoire presented by class II molecules. Variations in DM levels may therefore have a profound effect on the antigenic focus of T cell-mediated immune responses. Specifically, DM expression may influence susceptibility and resistance to autoimmune ...
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15 صفحه اولStudies of HLA-DM in Antigen Presentation and CD4+ T Cell Epitope Selection: A Dissertation
Antigen presented to CD4+ T cells by major histocompatibility complex class II molecules (MHCII) plays a key role in adaptive immunity. Antigen presentation is initiated by the proteolytic cleavage of pathogenic or self proteins and loading of resultant peptides to MHCII. The loading and exchange of peptides to MHCII is catalyzed by a nonclassical MHCII molecule, HLA-DM (DM). It is well establi...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2003
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.171.2.853